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[기본] Science Immunology Notification for 17 May 2024

사단법인과학키움 2024.05.18 08:49 조회 14
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Science Immunology
VOLUME 9 | ISSUE 95 | 17 MAY 2024
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RESEARCH ARTICLE  |  NEUROINFLAMMATION
A TH17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
BY WILLIAM A. MILLER-LITTLE, XING CHEN, ET AL.
IL-1β mediates steroid resistance in TH17 cells via a STAT5-dependent mechanism during autoimmune CNS inflammation.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression
BY MICHAEL P. PLEBANEK, YUE XUE, ET AL.
Tumor-derived lactate drives mregDC development and immunotolerant function by activating a SREBP2-dependent transcriptional program.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy
BY BLANDA DI LUCCIA, MARTINA MOLGORA, ET AL.
PD-1 blockade in the absence of TREM2 biases gut macrophages and microbiota toward inflammatory programs and enhances tumor control.
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RESEARCH ARTICLE  |  IMMUNOTHERAPY
LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
BY HIEU MINH TA, DIA ROY, ET AL.
LRIG1 is an inhibitory receptor that engages ligand VISTA and impairs antitumor T cell responses.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
BY MICHAEL KILIAN, MIRCO J. FRIEDRICH, ET AL.
B7H6 protein flags activated T cells for clearance by NK cells, and its genetic deletion enhances T cell proliferation and persistence.
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RESEARCH ARTICLE  |  IMMUNOTHERAPY
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity
BY CHUAN QIN, MIN ZHANG, ET AL.
CAR T cells display distinctive profiles and actions in patients with CNS autoimmunity.
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RESEARCH ARTICLE  |  NEUROIMMUNOLOGY
Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis
BY RUI LI, YANTING LEI, ET AL.
OXPHOS-derived ATP and its metabolites modulate the balance of B cell cytokines in health and disease.
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RESEARCH ARTICLE  |  T CELLS
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells
BY ALESSANDRO VACCHINI, ANDREW CHANCELLOR, ET AL.
Carbonyl adducts of nucleobases are MR1-presented self-antigens recognized by T cells.
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RESEARCH ARTICLE  |  VACCINES
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
BY XUESONG WANG, CHRISTOPHER A. COTTRELL, ET AL.
mRNA-LNP prime and boost immunogens can drive the maturation of multiple VRC01 precursors in the same host.
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