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[기본] Science Immunology Notification for 17 May 2024
사단법인과학키움
2024.05.18 08:49
조회 14
Brought to you by BioLegend
VOLUME 9 | ISSUE 95 | 17 MAY 2024
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RESEARCH ARTICLE
|
NEUROINFLAMMATION
A T
H
17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
BY WILLIAM A. MILLER-LITTLE, XING CHEN,
ET AL.
IL-1β mediates steroid resistance in T
H
17 cells via a STAT5-dependent mechanism during autoimmune CNS inflammation.
READ MORE
RESEARCH ARTICLE
|
CANCER IMMUNOLOGY
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression
BY MICHAEL P. PLEBANEK, YUE XUE,
ET AL.
Tumor-derived lactate drives mregDC development and immunotolerant function by activating a SREBP2-dependent transcriptional program.
READ MORE
RESEARCH ARTICLE
|
CANCER IMMUNOLOGY
TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy
BY BLANDA DI LUCCIA, MARTINA MOLGORA,
ET AL.
PD-1 blockade in the absence of TREM2 biases gut macrophages and microbiota toward inflammatory programs and enhances tumor control.
READ MORE
RESEARCH ARTICLE
|
IMMUNOTHERAPY
LRIG1 engages ligand VISTA and impairs tumor-specific CD8
+
T cell responses
BY HIEU MINH TA, DIA ROY,
ET AL.
LRIG1 is an inhibitory receptor that engages ligand VISTA and impairs antitumor T cell responses.
READ MORE
RESEARCH ARTICLE
|
CANCER IMMUNOLOGY
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
BY MICHAEL KILIAN, MIRCO J. FRIEDRICH,
ET AL.
B7H6 protein flags activated T cells for clearance by NK cells, and its genetic deletion enhances T cell proliferation and persistence.
READ MORE
RESEARCH ARTICLE
|
IMMUNOTHERAPY
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity
BY CHUAN QIN, MIN ZHANG,
ET AL.
CAR T cells display distinctive profiles and actions in patients with CNS autoimmunity.
READ MORE
RESEARCH ARTICLE
|
NEUROIMMUNOLOGY
Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis
BY RUI LI, YANTING LEI,
ET AL.
OXPHOS-derived ATP and its metabolites modulate the balance of B cell cytokines in health and disease.
READ MORE
RESEARCH ARTICLE
|
T CELLS
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells
BY ALESSANDRO VACCHINI, ANDREW CHANCELLOR,
ET AL.
Carbonyl adducts of nucleobases are MR1-presented self-antigens recognized by T cells.
READ MORE
RESEARCH ARTICLE
|
VACCINES
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
BY XUESONG WANG, CHRISTOPHER A. COTTRELL,
ET AL.
mRNA-LNP prime and boost immunogens can drive the maturation of multiple VRC01 precursors in the same host.
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Table of Contents for 17 May 2024; Vol. 384, No. 6697