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[기본] Science Immunology Notification for 31 May 2024

사단법인과학키움 2024.06.02 09:00 조회 17

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The Vilcek Foundation
Science Immunology
VOLUME 9 | ISSUE 95 | 31 MAY 2024
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RESEARCH ARTICLE  |  NEUROINFLAMMATION
A TH17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
BY WILLIAM A. MILLER-LITTLE, XING CHEN, ET AL.
IL-1β mediates steroid resistance in TH17 cells via a STAT5-dependent mechanism during autoimmune CNS inflammation.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site
BY MUNETOMO TAKAHASHI, TSZ Y. SO, ET AL.
An antigen signaling fate-mapping mouse reveals that intratumoral antigen signals trap CD8+ T cell clonal populations in tumors.
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RESEARCH ARTICLE  |  INNATE IMMUNITY
Heart failure promotes multimorbidity through innate immune memory
BY YUKITERU NAKAYAMA, KATSUHITO FUJIU, ET AL.
The innate memory of heart failure provokes recurrent heart failure and multimorbidity.
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RESEARCH ARTICLE  |  IMMUNODEFICIENCY
NUDCD3 deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome
BY RUI CHEN, ELENA LUKIANOVA, ET AL.
Developing T and B cells show a conserved requirement for NUDCD3 to support recombinase-mediated shuffling of antigen receptor genes.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression
BY MICHAEL P. PLEBANEK, YUE XUE, ET AL.
Tumor-derived lactate drives mregDC development and immunotolerant function by activating a SREBP2-dependent transcriptional program.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy
BY BLANDA DI LUCCIA, MARTINA MOLGORA, ET AL.
PD-1 blockade in the absence of TREM2 biases gut macrophages and microbiota toward inflammatory programs and enhances tumor control.
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RESEARCH ARTICLE  |  IMMUNOTHERAPY
LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
BY HIEU MINH TA, DIA ROY, ET AL.
LRIG1 is an inhibitory receptor that engages ligand VISTA and impairs antitumor T cell responses.
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RESEARCH ARTICLE  |  INNATE LYMPHOID CELLS
GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs
BY QIUTONG HUANG, WANG H. J. CAO, ET AL.
GFI1B is critical for the formation of lung-resident ILC2s that regulate inflammation and protect against tumor establishment.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance
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