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[기본] Science Immunology Notification for 14 June 2024
사단법인과학키움
2024.06.15 09:14
조회 126
Brought to you by Jackson Immuno Research
VOLUME 9 | ISSUE 96 | 14 JUN 2024
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Science
Immunology on
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FOCUS
|
INNATE IMMUNITY
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses
BY STEPHANIE A. RAGLAND, JONATHAN C. KAGAN
Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang
et al.
).
READ MORE
RESEARCH ARTICLE
|
T CELLS
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
BY LEON U. B. ENK, MALTE HELLMIG,
ET AL.
A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity.
READ MORE
RESEARCH ARTICLE
|
CANCER IMMUNOLOGY
Overexpression of
Malat1
drives metastasis through inflammatory reprogramming of the tumor microenvironment
BY ELENA MARTINEZ-TERROBA, LEAH M. PLASEK-HEGDE,
ET AL.
Malat1
-overexpressing tumors secrete Ccl2 to promote macrophage recruitment and lung adenocarcinoma progression.
READ MORE
RESEARCH ARTICLE
|
INNATE IMMUNITY
Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA
BY PENG ZHANG, XIAOQING HU,
ET AL.
Recognition of intracellular ssDNA containing CGT motifs by Schlafen 11 activates cytokine expression and cell death.
READ MORE
RESEARCH ARTICLE
|
T CELL MEMORY
Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes
BY TAYLOR A. HEIM, AUSTIN C. SCHULTZ,
ET AL.
T cells egress out of virally infected skin via afferent lymphatic vessels and form protective, long-lived lymph node–resident memory.
READ MORE
RESEARCH ARTICLE
|
MYELOID CELLS
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells
BY BENJAMIN Y. WINER, ALEXANDER H. SETTLE,
ET AL.
Plasma membrane abundance controls myeloid cell phagocytosis, migration, and in vivo responses against fungal pathogens.
READ MORE
RESEARCH ARTICLE
|
HUMAN IMMUNOLOGY
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
BY JOSHUA I. GRAY, DANIEL P. CARON,
ET AL.
Human tissue γδ T cells are diverse and functionally heterogeneous in early life and differentiate into disseminated effectors in adults.
READ MORE
EDITORS' CHOICE
|
FOCIS HIGHLIGHTS
Hide-&-Go-PhiP-Seq: Finding an elusive predictive MS biomarker
BY ANNABEL WALLACE, KEVIN C. O’CONNOR
Whole-proteome autoantibody profiling reveals an immunological signature that predates the clinical onset of multiple sclerosis.
READ MORE
EDITORS' CHOICE
|
FOCIS HIGHLIGHTS
The aMPPle differentiation potential of T
H
2 cells in human allergy
BY SINDHURA SIDDAPUREDDY, STEPHANIE EISENBARTH
Single-cell studies of human tissues reveal a stemlike T
H
2 subset as progenitors of key effectors in chronic type 2 inflammation.
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다음글 |
Science Advances Notification for 14 June 2024
이전글 |
Table of Contents for 14 June 2024; Vol. 384, No. 6701