Brought to you by Science Careers VOLUME 9 | ISSUE 96 | 21 JUN 2024 Follow Science Immunology on Twitter. We tweet regularly about our newest articles and share items of broad interest to the global community of immunologists. FOCUS  |  INNATE IMMUNITY Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses BY STEPHANIE A. RAGLAND, JONATHAN C. KAGAN Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al.). READ MORE RESEARCH ARTICLE  |  T CELLS Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening BY LEON U. B. ENK, MALTE HELLMIG, ET AL. A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity. READ MORE RESEARCH ARTICLE  |  CANCER IMMUNOLOGY Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment BY ELENA MARTINEZ-TERROBA, LEAH M. PLASEK-HEGDE, ET AL. Malat1-overexpressing tumors secrete Ccl2 to promote macrophage recruitment and lung adenocarcinoma progression. READ MORE RESEARCH ARTICLE  |  INFLAMMATORY BOWEL DISEASE MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis BY YARA EL MORR, MARIELA FÜRSTENHEIM, ET AL. Beneficial interactions occur between MAIT cells and the microbiota during intestinal inflammation. READ MORE RESEARCH ARTICLE  |  INNATE IMMUNITY Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA BY PENG ZHANG, XIAOQING HU, ET AL. Recognition of intracellular ssDNA containing CGT motifs by Schlafen 11 activates cytokine expression and cell death. READ MORE RESEARCH ARTICLE  |  CORONAVIRUS SARS-CoV-2 inflammation durably imprints memory CD4 T cells BY SOPHIE L. GRAY-GAILLARD, SABRINA M. SOLIS, ET AL. High-grade inflammation due to SARS-CoV-2 infection imparts a durable transcriptional and epigenetic imprint on memory CD4 T cells. READ MORE RESEARCH ARTICLE  |  T CELL MEMORY Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes BY TAYLOR A. HEIM, AUSTIN C. SCHULTZ, ET AL. T cells egress out of virally infected skin via afferent lymphatic vessels and form protective, long-lived lymph node–resident memory. READ MORE RESEARCH ARTICLE  |  MYELOID CELLS Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells BY BENJAMIN Y. WINER, ALEXANDER H. SETTLE, ET AL. Plasma membrane abundance controls myeloid cell phagocytosis, migration, and in vivo responses against fungal pathogens. READ MORE RESEARCH ARTICLE  |  HUMAN IMMUNOLOGY Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span BY JOSHUA I. GRAY, DANIEL P. CARON, ET AL. sciimmunolv9n96(240622).jpg 다운로드횟수[0] 목록 다음글 | New articles from eLife – June 26, 2024 이전글 | Table of Contents for 21 June 2024; Vol. 384, No. 6702