Brought to you by Science CareersVOLUME 9 | ISSUE 96 | 21 JUN 2024Follow Science Immunology on Twitter. We tweet regularly about our newest articles and share items of broad interest to the global community of immunologists.FOCUS | INNATE IMMUNITYWaking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responsesBY STEPHANIE A. RAGLAND, JONATHAN C. KAGANSingle-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al.).READ MORERESEARCH ARTICLE | T CELLSTargeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screeningBY LEON U. B. ENK, MALTE HELLMIG, ET AL.A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity.READ MORERESEARCH ARTICLE | CANCER IMMUNOLOGYOverexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironmentBY ELENA MARTINEZ-TERROBA, LEAH M. PLASEK-HEGDE, ET AL.Malat1-overexpressing tumors secrete Ccl2 to promote macrophage recruitment and lung adenocarcinoma progression.READ MORERESEARCH ARTICLE | INFLAMMATORY BOWEL DISEASEMAIT cells monitor intestinal dysbiosis and contribute to host protection during colitisBY YARA EL MORR, MARIELA FÜRSTENHEIM, ET AL.Beneficial interactions occur between MAIT cells and the microbiota during intestinal inflammation.READ MORERESEARCH ARTICLE | INNATE IMMUNITYSchlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNABY PENG ZHANG, XIAOQING HU, ET AL.Recognition of intracellular ssDNA containing CGT motifs by Schlafen 11 activates cytokine expression and cell death.READ MORERESEARCH ARTICLE | CORONAVIRUSSARS-CoV-2 inflammation durably imprints memory CD4 T cellsBY SOPHIE L. GRAY-GAILLARD, SABRINA M. SOLIS, ET AL.High-grade inflammation due to SARS-CoV-2 infection imparts a durable transcriptional and epigenetic imprint on memory CD4 T cells.READ MORERESEARCH ARTICLE | T CELL MEMORYLymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodesBY TAYLOR A. HEIM, AUSTIN C. SCHULTZ, ET AL.T cells egress out of virally infected skin via afferent lymphatic vessels and form protective, long-lived lymph node–resident memory.READ MORERESEARCH ARTICLE | MYELOID CELLSPlasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cellsBY BENJAMIN Y. WINER, ALEXANDER H. SETTLE, ET AL.Plasma membrane abundance controls myeloid cell phagocytosis, migration, and in vivo responses against fungal pathogens.READ MORERESEARCH ARTICLE | HUMAN IMMUNOLOGYHuman γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life spanBY JOSHUA I. GRAY, DANIEL P. CARON, ET AL.sciimmunolv9n96(240622).jpg 다운로드횟수[0] 목록 다음글 | New articles from eLife – June 26, 2024 이전글 | Table of Contents for 21 June 2024; Vol. 384, No. 6702