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| | LETTER | | Stop elephant hunting in Tanzania borderlands | | BY JOYCE POOLE, ANDREW DOBSON, ET AL. | 27 JUN 2024 | | In 2023–2024, “sport” hunters legally shot and killed five elephants in northern Tanzania (1). The targeted elephants were among the largest, oldest bulls from the cross-border population studied by Kenya’s 51-year Amboseli Elephant Research Project, the longest study of elephants in the world (2). Unlike in Tanzania, hunting elephants has been banned in Kenya for 50 years (3). Until now, except for transgressions in 1994 (4 ), permitted hunters in Tanzania have not targeted this population, which is known as one of the last gene pools for enormous ivory and the source of the largest tusks ever collected (5). Moving forward, Tanzania should stop issuing hunting permits that lead to the killing of these cross-border elephants. | |
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| RESEARCH ARTICLE | | GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans | | BY KYU SIK KIM, JOON SEOK PARK, ET AL. | 27 JUN 2024 | | GLP-1 receptor agonists (GLP-1RAs) are effective anti-obesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to obese patients and observed heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1R neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMHGLP-1R neurons caused satiation. Calcium imaging demonstrated that these neurons are actively involved in encoding preingestive satiation. GLP-1RA administration increased the activity of DMHGLP-1R neurons selectively during eating behavior. We further identified an intricate interplay between DMHGLP-1R neurons and arcuate NPY/AgRP neurons (ARCNPY/AgRP), to regulate food intake. Our findings reveal a hypothalamic mechanism through which GLP-1RAs control preingestive satiation, offering novel neural targets for obesity and metabolic diseases. | |
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