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[기본] Science Immunology Notification for 28 June 2024

사단법인과학키움 2024.06.30 07:17 조회 2
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Science Immunology
VOLUME 9 | ISSUE 96 | 28 JUN 2024
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FOCUS  |  INNATE IMMUNITY
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses
BY STEPHANIE A. RAGLAND, JONATHAN C. KAGAN
Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al.).
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RESEARCH ARTICLE  |  T CELLS
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
BY LEON U. B. ENK, MALTE HELLMIG, ET AL.
A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity.
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RESEARCH ARTICLE  |  CANCER IMMUNOLOGY
Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment
BY ELENA MARTINEZ-TERROBA, LEAH M. PLASEK-HEGDE, ET AL.
Malat1-overexpressing tumors secrete Ccl2 to promote macrophage recruitment and lung adenocarcinoma progression.
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RESEARCH ARTICLE  |  INFLAMMATORY BOWEL DISEASE
MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis
BY YARA EL MORR, MARIELA FÜRSTENHEIM, ET AL.
Beneficial interactions occur between MAIT cells and the microbiota during intestinal inflammation.
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RESEARCH ARTICLE  |  T CELLS
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity
BY MIGUEL DE JESUS, ALEXANDER H. SETTLE, ET AL.
Cytotoxic T cells form topographically complex, undulatory immune synapses with their targets to promote killing.
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RESEARCH ARTICLE  |  INNATE IMMUNITY
Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA
BY PENG ZHANG, XIAOQING HU, ET AL.
Recognition of intracellular ssDNA containing CGT motifs by Schlafen 11 activates cytokine expression and cell death.
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RESEARCH ARTICLE  |  T CELLS
Circulating KLRG1+ long-lived effector memory T cells retain the flexibility to become tissue resident
BY ERIN D. LUCAS, MATTHEW A. HUGGINS, ET AL.
Circulating KLRG1+ memory T cells rapidly enter nonlymphoid tissues after viral infection and differentiate into resident memory.
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RESEARCH ARTICLE  |  CORONAVIRUS
SARS-CoV-2 inflammation durably imprints memory CD4 T cells
BY SOPHIE L. GRAY-GAILLARD, SABRINA M. SOLIS, ET AL.
High-grade inflammation due to SARS-CoV-2 infection imparts a durable transcriptional and epigenetic imprint on memory CD4 T cells.
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RESEARCH ARTICLE  |  NK CELLS
Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation
BY JENNIFER A. FOLTZ, JENNIFER TRAN, ET AL.
IL-12/15/18 differentially activate cNK cell subsets driving unique memory-like programs with implications for NK cell therapy.