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[기본] New articles from eLife – December 18, 2024

사단법인과학키움 2024.12.19 06:14 조회 1677

 
 

December 18, 2024

New articles from eLife

 

 

We’re looking for research on the history, current state and future of innate immune memory studies in our latest Focus Issue

MAGAZINE

Cell Biology

Rearranging to resist cell death

Dominik Brokatzky, Serge Mostowy

Cytoskeleton rearrangements promote formation of a giant structure called a GUVac that stops cells from dying when they become detached from the extracellular matrix.

REVIEWED PREPRINTS

VERSIONS OF RECORD

Structural Biology and Molecular Biophysics

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis

A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.

Structural Biology and Molecular Biophysics

Isoleucine gate blocks K+ conduction in C-type inactivation

Werner Treptow, Yichen Liu ... Benoit Roux

The conformation of an isoleucine gate located along the TM6 segment on the intracellular side below the selectivity filter is a critical component leading to a non-conductive state in the C-type inactivation process of K+ channels.

Biochemistry and Chemical BiologyNeuroscience

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

Eyal Paz, Sahil Jain ... Abdussalam Azem

TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.

Biochemistry and Chemical BiologyStructural Biology and Molecular Biophysics

Control of 3′ splice site selection by the yeast splicing factor Fyv6

Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins

The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.