New articles from eLife

Neuroscience

How vision shapes the paths we choose

Arthur D Kuo

A mathematical model can predict the path walkers take through a rugged landscape, including the tendency of people to avoid paths that are too steep, even if it means going farther.

Immunology and Inflammation, Evolutionary Biology

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty

Neuroscience

Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection

Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon

Medicine

Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

Feilin Cao, Zhaosheng Ma ... Shifen Huang

Neuroscience

Beyond gradients: Factorized, geometric control of interference and generalization

Daniel N Scott, Michael J Frank

Cell Biology

Control of cell retraction and protrusion with a single protein

Jean De Seze, Maud Bongaerts ... Mathieu Coppey

Immunology and Inflammation, Microbiology and Infectious Disease

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

Marisa S Egan, Emily A O’Rourke ... Sunny Shin

Cell Biology

Calcium tunneling through the ER and transfer to other organelles for optimal signaling in Toxoplasma gondii

Zhu-Hong Li, Beejan Asady ... Silvia NJ Moreno

Cell Biology, Neuroscience

A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

Jun Sun, Francisca Rojo-Cortés ... Alicia Hidalgo

Cell Biology, Genetics and Genomics

Kinesin Autoinhibition Requires Elbow Phosphorylation

Guanghan Chen, Zhengyang Guo ... Guangshuo Ou

Neuroscience

Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw

Chromosomes and Gene Expression

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch

Biochemistry and Chemical Biology, Structural Biology and Molecular Biophysics

AI-Based Discovery and CryoEM Structural Elucidation of a K_ATP Channel Pharmacochaperone

Assmaa ElSheikh, Camden M Driggers ... Show-Ling Shyng

Developmental Biology, Stem Cells and Regenerative Medicine

The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

Kara A Nelson, Kari F Lenhart ... Stephen DiNardo

Neuroscience

Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

Jan H Kirchner, Lucas Euler ... Julijana Gjorgjieva

Neuroscience

Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation

Jie Wang, Jun Nishiyama ... Ryohei Yasuda

Genetics and Genomics, Computational and Systems Biology

Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

Luke J Dillard, Gina M Calabrese ... Charles R Farber

Cell Biology, Neuroscience

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

Dhanesh Sivadasan Bindu, Justin T Savage ... Cagla Eroglu

Neuroscience

Minimal background noise enhances neural speech tracking: Evidence of stochastic resonance

Björn Herrmann

Neuroscience

Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects

Brian C Ruyle, Sarah Masud ... Jose A Moron

Medicine, Neuroscience

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: a safety study

Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt

Neuroscience

Valence and Salience Encoding in the Central Amygdala

Mi-Seon Kong, Ethan Ancell ... Larry S Zweifel

Genetics and Genomics

Reported transgenerational responses to Pseudomonas aeruginosa in C. elegans are not robust

D Patrick Gainey, Andrey V Shubin, Craig P Hunter

Neuroscience

Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

Bhanu Priya Somashekar, Upinder Singh Bhalla

Cell Biology

Rejuvenating aged osteoprogenitors for bone repair

Joshua Reeves, Pierre Tournier ... Shukry J Habib

Physics of Living Systems

Escape problem of magnetotactic bacteria - physiological magnetic field strengths help magnetotactic bacteria navigate in simulated sediments

Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp

Neuroscience

Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

Sergio Casas-Tintó, Nuria García-Guillen, Maria Losada-Pérez

Neuroscience

High-resolution awake mouse fMRI at 14 Tesla

David Hike, Xiaochen Liu ... Xin Yu

Neuroscience

The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

Lian Hollander Cohen, Omer Cohen ... Berta Levavi Sivan

Developmental Biology

Skeletal Muscle Satellite Cells Co-Opt the Tenogenic Gene Scleraxis to Instruct Regeneration

Yun Bai, Tyler Harvey ... Chen-Ming Fan

Cell Biology, Developmental Biology

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

Qian Wang, Hongge Li ... Xin Zhang

Computational and Systems Biology, Evolutionary Biology

Quantifying microbial fitness in high-throughput experiments

Justus Wilhelm Fink, Michael Manhart

Structural Biology and Molecular Biophysics

Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

Kei Wada, Kenji Kobayashi ... Masaki Unno

Neuroscience

Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

Krzysztof Hubert Olszyński, Rafał Polowy ... Robert Kuba Filipkowski

When exposed to prolonged stressful stimulation, rats start to emit long, frequency-unmodulated 44-kHz ultrasonic vocalizations, usually within the 35–50 kHz range, along with, previously described, long and unmodulated 22-kHz ultrasonic vocalizations.

Developmental Biology

Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

Max Henry Hills, Limei Ma ... C Ron Yu

A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.