| Brought to you by New England Biolabs |  |
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| | |  | | VOLUME 386 | ISSUE 6727 | 13 DEC 2024 |
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| |  | Special Issue |
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| Special Issue News | 2024 Breakthrough of the Year | | The long shot | | By Jon Cohen | | An injectable HIV drug with a novel mechanism shows remarkable ability to prevent infection | |
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| Special Issue News | 2024 Breakthrough of the Year | | Runners-up | | By Paul Voosen, Elizabeth Pennisi, et al. | |
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| Special Issue News | 2024 Breakthrough of the Year | | Breakdowns of the year | | By Martin Enserink, David Malakoff, et al. | | What went wrong in the world of science | |
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| Editorial |
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| News |
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